相互作用
Cyclosporin + Darolutamide
重症度: 中等度
Cyclosporin and Darolutamide: moderate interaction.
最終更新日
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概要
Cyclosporine inhibits both P-gp and CYP3A4, and darolutamide is a substrate of both, so darolutamide exposure may increase. This could heighten adverse effects such as fatigue and cardiac or hepatic events.
この相互作用をわかりやすく説明すると
Cyclosporin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Darolutamide belongs to Miscellaneous.
なぜ起こるのか
Combined P-gp and CYP3A4 inhibition by cyclosporine increases darolutamide absorption and reduces clearance.
対処法
Monitor for darolutamide adverse reactions and reduce the dose if they emerge. Consider an alternative immunosuppressant if feasible.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとDarolutamideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Darolutamideのその他の相互作用
よくある質問
Can I take Cyclosporin with Darolutamide?
MediHelp rates the interaction as moderate. Cyclosporin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits both P-gp and CYP3A4, and darolutamide is a substrate of both, so darolutamide exposure may increase. This could heighten adverse effects such as fatigue and cardiac or hepatic events.
How serious is the interaction between Cyclosporin and Darolutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darolutamide adverse reactions and reduce the dose if they emerge. Consider an alternative immunosuppressant if feasible.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
