相互作用
Cyclosporin + Metreleptin
重症度: 中等度
Cyclosporin and Metreleptin: moderate interaction.
最終更新日
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概要
Metreleptin may change cyclosporine metabolism via effects on CYP450 enzymes, leading to unpredictable blood levels. Subtherapeutic or toxic levels may result.
この相互作用をわかりやすく説明すると
Cyclosporin and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Metreleptin belongs to Endocrine.
なぜ起こるのか
Leptin may alter CYP450 expression, and metabolic improvement may change cyclosporine clearance.
対処法
Monitor cyclosporine trough concentrations and renal function when starting, adjusting or stopping metreleptin, and adjust the dose.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとMetreleptinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Metreleptinのその他の相互作用
Cyclosporinのその他の相互作用
よくある質問
Can I take Cyclosporin with Metreleptin?
MediHelp rates the interaction as moderate. Cyclosporin and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin may change cyclosporine metabolism via effects on CYP450 enzymes, leading to unpredictable blood levels. Subtherapeutic or toxic levels may result.
How serious is the interaction between Cyclosporin and Metreleptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function when starting, adjusting or stopping metreleptin, and adjust the dose.
What other medicines interact with Metreleptin?
MediHelp also lists interactions of Metreleptin with, for example, Insulin aspart, Insulin glargine-lixisenatide, Insulin glargine. The full list is on the Metreleptin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
