相互作用
Cyclosporin + Simvastatin
重症度: 併用禁忌
Cyclosporin and Simvastatin: contraindicated interaction.
最終更新日
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概要
Cyclosporine inhibits CYP3A4 and OATP1B1 and markedly raises simvastatin acid exposure. The risk of myopathy and rhabdomyolysis is high.
この相互作用をわかりやすく説明すると
Cyclosporin and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
なぜ起こるのか
CYP3A4 and OATP1B1 inhibition raises simvastatin exposure
対処法
Contraindicated by labelling; use a different statin (for example pravastatin or rosuvastatin at a limited dose).
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとSimvastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Simvastatinのその他の相互作用
よくある質問
Can I take Cyclosporin with Simvastatin?
MediHelp rates the interaction as contraindicated. Cyclosporin and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine inhibits CYP3A4 and OATP1B1 and markedly raises simvastatin acid exposure. The risk of myopathy and rhabdomyolysis is high.
How serious is the interaction between Cyclosporin and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated by labelling; use a different statin (for example pravastatin or rosuvastatin at a limited dose).
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
