相互作用
Danazol + Simvastatin
重症度: 併用禁忌
Danazol and Simvastatin: contraindicated interaction.
最終更新日
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概要
Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
この相互作用をわかりやすく説明すると
Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Danazol inhibits CYP3A4 and so reduces the metabolism of simvastatin, increasing systemic exposure.
対処法
Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DanazolとSimvastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Simvastatinのその他の相互作用
よくある質問
Can I take Danazol with Simvastatin?
MediHelp rates the interaction as contraindicated. Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
How serious is the interaction between Danazol and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
