相互作用
Cyclosporine + Metformin-repaglinide
重症度: 重大
Cyclosporine and Metformin-repaglinide: major interaction.
最終更新日
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概要
Cyclosporine substantially increases repaglinide exposure, raising the risk of hypoglycemia. The effect is greater at low repaglinide doses and needs dose limitation.
この相互作用をわかりやすく説明すると
Cyclosporine and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Inhibition of CYP3A4 and OATP1B1-mediated hepatic uptake and metabolism of repaglinide by cyclosporine.
対処法
Limit the repaglinide daily dose and monitor blood glucose more often; consider an alternative antidiabetic agent if hypoglycemia occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporineとMetformin-repaglinideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Metformin-repaglinideのその他の相互作用
よくある質問
Can I take Cyclosporine with Metformin-repaglinide?
MediHelp rates the interaction as major. Cyclosporine and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine substantially increases repaglinide exposure, raising the risk of hypoglycemia. The effect is greater at low repaglinide doses and needs dose limitation.
How serious is the interaction between Cyclosporine and Metformin-repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the repaglinide daily dose and monitor blood glucose more often; consider an alternative antidiabetic agent if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
