相互作用
Gemfibrozil + Metformin-repaglinide
重症度: 併用禁忌
Gemfibrozil and Metformin-repaglinide: contraindicated interaction.
最終更新日
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概要
Gemfibrozil and its glucuronide strongly inhibit CYP2C8 and OATP1B1, the main clearance pathways of repaglinide, raising repaglinide exposure several-fold. Prolonged and severe hypoglycaemia can result. The metformin component adds little to this effect.
この相互作用をわかりやすく説明すると
Gemfibrozil and Metformin-repaglinide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemfibrozil belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
なぜ起こるのか
CYP2C8/OATP1B1 inhibition markedly increases repaglinide exposure
対処法
Contraindicated; use a different lipid-lowering agent or glucose-lowering drug and monitor glucose if the change is made.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、GemfibrozilとMetformin-repaglinideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Metformin-repaglinideのその他の相互作用
Gemfibrozilのその他の相互作用
よくある質問
Can I take Gemfibrozil with Metformin-repaglinide?
MediHelp rates the interaction as contraindicated. Gemfibrozil and Metformin-repaglinide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil and its glucuronide strongly inhibit CYP2C8 and OATP1B1, the main clearance pathways of repaglinide, raising repaglinide exposure several-fold. Prolonged and severe hypoglycaemia can result. The metformin component adds little to this effect.
How serious is the interaction between Gemfibrozil and Metformin-repaglinide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; use a different lipid-lowering agent or glucose-lowering drug and monitor glucose if the change is made.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Apalutamide, Clarithromycin, Clopidogrel. The full list is on the Metformin-repaglinide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
