相互作用
Dapsone + Pyrimethamine
重症度: 中等度
Dapsone and Pyrimethamine: moderate interaction.
最終更新日
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概要
Dapsone and pyrimethamine are used together for toxoplasmosis and malaria prophylaxis, but both can cause hematologic toxicity. Pyrimethamine is an antifolate that can cause bone marrow suppression, and dapsone can cause hemolysis and methemoglobinemia. The combination increases the risk of anemia, neutropenia and thrombocytopenia.
この相互作用をわかりやすく説明すると
Dapsone and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Pyrimethamine belongs to Anti Parasitic.
なぜ起こるのか
Additive hematologic toxicity: antifolate marrow suppression from pyrimethamine plus oxidative hemolysis from dapsone.
対処法
Screen for G6PD deficiency and monitor complete blood counts regularly. Give folinic acid with pyrimethamine as recommended in treatment protocols.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DapsoneとPyrimethamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dapsoneのその他の相互作用
Pyrimethamineのその他の相互作用
よくある質問
Can I take Dapsone with Pyrimethamine?
MediHelp rates the interaction as moderate. Dapsone and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapsone and pyrimethamine are used together for toxoplasmosis and malaria prophylaxis, but both can cause hematologic toxicity. Pyrimethamine is an antifolate that can cause bone marrow suppression, and dapsone can cause hemolysis and methemoglobinemia. The combination increases the risk of anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Dapsone and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Screen for G6PD deficiency and monitor complete blood counts regularly. Give folinic acid with pyrimethamine as recommended in treatment protocols.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
