相互作用
Darunavir + Erlotinib
重症度: 重大
Darunavir and Erlotinib: major interaction.
最終更新日
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概要
Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise erlotinib concentrations. This increases the risk of diarrhea, rash and other adverse effects.
この相互作用をわかりやすく説明すると
Darunavir and Erlotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Erlotinib belongs to Oncology.
なぜ起こるのか
Boosted darunavir inhibits CYP3A4, reducing erlotinib metabolism.
対処法
Consider an alternative antiretroviral regimen. If combined, monitor closely and reduce erlotinib dose in steps if severe reactions occur.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DarunavirとErlotinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Erlotinibのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Darunavir with Erlotinib?
MediHelp rates the interaction as major. Darunavir and Erlotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise erlotinib concentrations. This increases the risk of diarrhea, rash and other adverse effects.
How serious is the interaction between Darunavir and Erlotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiretroviral regimen. If combined, monitor closely and reduce erlotinib dose in steps if severe reactions occur.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
