相互作用
Darunavir + Tolvaptan
重症度: 併用禁忌
Darunavir and Tolvaptan: contraindicated interaction.
最終更新日
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概要
Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and is expected to increase tolvaptan exposure. This may cause excessive aquaresis, dehydration, and rapid sodium shifts.
この相互作用をわかりやすく説明すると
Darunavir and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Tolvaptan belongs to Endocrine.
なぜ起こるのか
CYP3A4 inhibition, boosted by ritonavir or cobicistat, reduces tolvaptan metabolism.
対処法
Avoid the combination; consider alternatives. If needed, monitor serum sodium and volume status closely.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DarunavirとTolvaptanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tolvaptanのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Darunavir with Tolvaptan?
MediHelp rates the interaction as contraindicated. Darunavir and Tolvaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and is expected to increase tolvaptan exposure. This may cause excessive aquaresis, dehydration, and rapid sodium shifts.
How serious is the interaction between Darunavir and Tolvaptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider alternatives. If needed, monitor serum sodium and volume status closely.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
