相互作用
Dasatinib + Pantoprazole
重症度: 重大
Dasatinib and Pantoprazole: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Dasatinib absorption depends on an acidic stomach, so a proton pump inhibitor can substantially reduce its exposure. This may compromise disease control.
この相互作用をわかりやすく説明すると
Dasatinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Elevated gastric pH reduces dasatinib solubility and absorption.
対処法
Avoid PPIs; use an antacid given about 2 hours before or after dasatinib, or an H2 antagonist given at least 2 hours after dasatinib if acid suppression is needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DasatinibとPantoprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dasatinibのその他の相互作用
Pantoprazoleのその他の相互作用
よくある質問
Can I take Dasatinib with Pantoprazole?
MediHelp rates the interaction as major. Dasatinib and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on an acidic stomach, so a proton pump inhibitor can substantially reduce its exposure. This may compromise disease control.
How serious is the interaction between Dasatinib and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs; use an antacid given about 2 hours before or after dasatinib, or an H2 antagonist given at least 2 hours after dasatinib if acid suppression is needed.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
