相互作用
Pantoprazole + Rilpivirine
重症度: 併用禁忌
Pantoprazole and Rilpivirine: contraindicated interaction.
最終更新日
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概要
Oral rilpivirine requires acidic gastric conditions for absorption, and pantoprazole markedly reduces its exposure. This can cause virologic failure and NNRTI resistance, and labeling contraindicates PPIs with oral rilpivirine.
この相互作用をわかりやすく説明すると
Pantoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pantoprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
なぜ起こるのか
Increased gastric pH from proton pump inhibition reduces rilpivirine dissolution and absorption.
対処法
Do not use together. Choose a different acid suppressant, such as an H2 blocker with timed separation, or an alternative antiretroviral.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、PantoprazoleとRilpivirineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pantoprazoleのその他の相互作用
Rilpivirineのその他の相互作用
よくある質問
Can I take Pantoprazole with Rilpivirine?
MediHelp rates the interaction as contraindicated. Pantoprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral rilpivirine requires acidic gastric conditions for absorption, and pantoprazole markedly reduces its exposure. This can cause virologic failure and NNRTI resistance, and labeling contraindicates PPIs with oral rilpivirine.
How serious is the interaction between Pantoprazole and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose a different acid suppressant, such as an H2 blocker with timed separation, or an alternative antiretroviral.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Acalabrutinib, Atazanavir, Dacomitinib. The full list is on the Pantoprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
