相互作用
Atazanavir + Pantoprazole
重症度: 重大
Atazanavir and Pantoprazole: major interaction.
最終更新日
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概要
Atazanavir needs an acidic environment for dissolution, and pantoprazole markedly reduces its absorption. This can lead to subtherapeutic antiretroviral levels, virologic failure and resistance.
この相互作用をわかりやすく説明すると
Atazanavir and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Pantoprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Elevated gastric pH reduces atazanavir solubility and oral absorption.
対処法
Avoid in treatment-experienced patients; in treatment-naive patients follow labeling with ritonavir boosting, limited PPI dose and staggered timing, with virologic monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとPantoprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Pantoprazoleのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Pantoprazole?
MediHelp rates the interaction as major. Atazanavir and Pantoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic environment for dissolution, and pantoprazole markedly reduces its absorption. This can lead to subtherapeutic antiretroviral levels, virologic failure and resistance.
How serious is the interaction between Atazanavir and Pantoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in treatment-experienced patients; in treatment-naive patients follow labeling with ritonavir boosting, limited PPI dose and staggered timing, with virologic monitoring.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Dacomitinib. The full list is on the Pantoprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
