相互作用
Dasatinib + Sodium bicarbonate
重症度: 中等度
Dasatinib and Sodium bicarbonate: moderate interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
この相互作用をわかりやすく説明すると
Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Sodium bicarbonate belongs to Gastrointestinal Tract.
なぜ起こるのか
Raised gastric pH reduces dissolution and absorption of dasatinib, which is a pH-dependent weak base.
対処法
If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DasatinibとSodium bicarbonateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dasatinibのその他の相互作用
Sodium bicarbonateのその他の相互作用
よくある質問
Can I take Dasatinib with Sodium bicarbonate?
MediHelp rates the interaction as moderate. Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
How serious is the interaction between Dasatinib and Sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
