Drug interactions
Dasatinib + Sodium bicarbonate
Severity: Moderate
Dasatinib and Sodium bicarbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
What this interaction means in plain words
Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH reduces dissolution and absorption of dasatinib, which is a pH-dependent weak base.
What to do
If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Dasatinib with Sodium bicarbonate?
MediHelp rates the interaction as moderate. Dasatinib and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib solubility falls as gastric pH rises, so antacids that neutralize acid can reduce its absorption. Lower exposure may reduce efficacy against leukemia.
How serious is the interaction between Dasatinib and Sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, give it at least 2 hours before or after dasatinib. Avoid routine long-term use around dosing.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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