相互作用
Delamanid + Ritonavir
重症度: 重大
Delamanid and Ritonavir: major interaction.
最終更新日
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概要
Ritonavir strongly inhibits CYP3A4 and modestly raises exposure to the delamanid metabolite DM-6705. Higher DM-6705 levels are associated with QT prolongation, and ritonavir-boosted regimens are often given with other QT-active drugs.
この相互作用をわかりやすく説明すると
Delamanid and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Delamanid belongs to Anti Bacterial; Ritonavir belongs to Anti Virals.
なぜ起こるのか
CYP3A4 inhibition by ritonavir reduces clearance of the delamanid metabolite DM-6705, increasing QT-prolonging exposure.
対処法
Perform frequent ECG monitoring from the start and throughout co-administration, and check potassium, magnesium and calcium. Avoid additional QT-prolonging drugs where possible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DelamanidとRitonavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Delamanidのその他の相互作用
Ritonavirのその他の相互作用
よくある質問
Can I take Delamanid with Ritonavir?
MediHelp rates the interaction as major. Delamanid and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir strongly inhibits CYP3A4 and modestly raises exposure to the delamanid metabolite DM-6705. Higher DM-6705 levels are associated with QT prolongation, and ritonavir-boosted regimens are often given with other QT-active drugs.
How serious is the interaction between Delamanid and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform frequent ECG monitoring from the start and throughout co-administration, and check potassium, magnesium and calcium. Avoid additional QT-prolonging drugs where possible.
What other medicines interact with Delamanid?
MediHelp also lists interactions of Delamanid with, for example, Carbamazepine, Rifampicin, Moxifloxacin. The full list is on the Delamanid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
