相互作用
Delamanid + Rifampicin
重症度: 併用禁忌
Delamanid and Rifampicin: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Rifampicin lowers delamanid exposure, with a reduction shown in pharmacokinetic studies. Lower levels may reduce efficacy in drug-resistant TB.
この相互作用をわかりやすく説明すると
Delamanid and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Delamanid belongs to Anti Bacterial; Rifampicin belongs to Anti Bacterial.
なぜ起こるのか
Rifampicin induces CYP3A4 and other enzymes, accelerating delamanid clearance.
対処法
Do not co-administer; rifampicin is typically not part of regimens for rifampicin-resistant TB requiring delamanid.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DelamanidとRifampicinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Delamanidのその他の相互作用
Rifampicinのその他の相互作用
よくある質問
Can I take Delamanid with Rifampicin?
MediHelp rates the interaction as contraindicated. Delamanid and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin lowers delamanid exposure, with a reduction shown in pharmacokinetic studies. Lower levels may reduce efficacy in drug-resistant TB.
How serious is the interaction between Delamanid and Rifampicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; rifampicin is typically not part of regimens for rifampicin-resistant TB requiring delamanid.
What other medicines interact with Delamanid?
MediHelp also lists interactions of Delamanid with, for example, Carbamazepine, Moxifloxacin, Ritonavir. The full list is on the Delamanid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
