相互作用
Deutetrabenazine + Phenelzine
重症度: 併用禁忌
Deutetrabenazine and Phenelzine: contraindicated interaction.
最終更新日
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概要
Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.
この相互作用をわかりやすく説明すると
Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
なぜ起こるのか
VMAT2 inhibition alters monoamine storage while MAO inhibition prevents their breakdown, causing unpredictable monoamine and pressor effects.
対処法
Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、DeutetrabenazineとPhenelzineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Phenelzineのその他の相互作用
Deutetrabenazineのその他の相互作用
よくある質問
Can I take Deutetrabenazine with Phenelzine?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.
How serious is the interaction between Deutetrabenazine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
