医薬品リファレンス

Deutetrabenazine

Deutetrabenazine is a medicine in the class central nervous system. It is used for tardive dyskinesia.

薬効分類: Central Nervous System
効能・効果: tardive dyskinesia

最終更新日 15 10月 2026 出典: US FDA label

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要点

薬効分類: Central Nervous System
ATCコード: N07XX16
一般的な剤形: 錠剤
既知の相互作用: 184 (併用禁忌: 8 · 重大: 16 · 中等度: 147 · 軽度: 13)
商品名: 3
国・市場: 2

剤形、規格、商品名は国によって異なります。お手元の製品をご確認ください。

何に使われるか

Tardive dyskinesia

作用のしくみ

Precise mechanism unknown; believed related to reversible depletion of monoamines (dopamine, serotonin, norepinephrine, histamine) from nerve terminals. Metabolites alpha-HTBZ and beta-HTBZ reversibly inhibit VMAT2.

成人の通常用量（添付文書の要約）

Chorea in Huntington's disease or tardive dyskinesia, Austedo XR: start 12 mg once daily orally; increase weekly by 6 mg per day based on response and tolerability; maximum 48 mg per day

添付文書の最初の用法・用量の行のみの要約です。用法・用量の全項目はアプリでご覧いただけます。

妊娠と授乳

妊娠: Unknown No adequate human data. Deutetrabenazine had no clear effect on fetal development in rats, but the related tetrabenazine, given through pregnancy and lactation, increased stillbirths and offspring deaths. Use only if the benefit justifies the risk.
授乳: Unknown No data on milk levels or infant effects. US label: weigh breastfeeding against the mother's need. If used, watch the infant for drowsiness and poor feeding.

報告されている副作用

Somnolence
Diarrhea
Dry mouth
Fatigue
Nasopharyngitis
Insomnia

警告（枠囲み警告）

Increases the risk of depression and suicidality in patients with Huntington's disease. Balance risks against the need to treat chorea; monitor for emergence or worsening of depression, suicidality or unusual behavior; inform patients, caregivers and families to report concerns promptly. Use caution with a history of depression or prior suicide attempts or ideation. Contraindicated in suicidal patients and in untreated or inadequately treated depression.

禁忌

Huntington's disease patients who are suicidal or have untreated or inadequately treated depression
Hepatic impairment
Taking reserpine; wait at least 20 days after stopping reserpine

注意が必要な方

Depression and suicidality in Huntington's disease; observe for new or worsening symptoms and consider discontinuing if they do not resolve
QT prolongation: avoid in congenital long QT syndrome and history of cardiac arrhythmias
Neuroleptic malignant syndrome: discontinue immediately if it occurs

妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。

主な相互作用 (184)

Deutetrabenazine + Isocarboxazid Contraindicated
Deutetrabenazine + Linezolid Contraindicated
Deutetrabenazine + Phenelzine Contraindicated
Deutetrabenazine + Rasagiline Contraindicated
Deutetrabenazine + Safinamide Contraindicated
Deutetrabenazine + Selegiline Contraindicated
Deutetrabenazine + Tranylcypromine Contraindicated
Deutetrabenazine + Valbenazine Contraindicated
Abiraterone + Deutetrabenazine Major
Bupropion + Deutetrabenazine Major

All 184 interactions, with severity and what to do

Pro+会員向け

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アカウントを作成してPro+トライアルを始めると、Deutetrabenazineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。

Dosing by age, kidney and liver function, and further dose lines
Renal and hepatic dose adjustments
Dosing in older adults
How to give it
Pharmacokinetics
Patient counselling points
Food interactions

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よくある質問

What is Deutetrabenazine used for?

Deutetrabenazine is a medicine in the class central nervous system. It is used for Tardive dyskinesia.

What side effects have been reported with Deutetrabenazine?

Somnolence, Diarrhea, Dry mouth, Fatigue, Nasopharyngitis, Insomnia. Serious warning: Increases the risk of depression and suicidality in patients with Huntington's disease.

Can Deutetrabenazine be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. No adequate human data. Deutetrabenazine had no clear effect on fetal development in rats, but the related tetrabenazine, given through pregnancy and lactation, increased stillbirths and offspring deaths. Use only if the benefit justifies the risk. Breastfeeding: Unknown. No data on milk levels or infant effects. US label: weigh breastfeeding against the mother's need. If used, watch the infant for drowsiness and poor feeding.

What does Deutetrabenazine interact with?

MediHelp lists 184 known interactions for Deutetrabenazine. Contraindicated: 8 · Major: 16 · Moderate: 147 · Minor: 13. The most serious include Isocarboxazid, Linezolid, Phenelzine.

完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで

MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。

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