相互作用
Donepezil + Rivastigmine
重症度: 重大
Donepezil and Rivastigmine: major interaction.
最終更新日
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概要
Both are cholinesterase inhibitors used for dementia, so combining them adds cholinergic toxicity without a proven benefit. Patients may develop nausea, vomiting, diarrhea, bradycardia and syncope.
この相互作用をわかりやすく説明すると
Donepezil and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Donepezil belongs to Central Nervous System; Rivastigmine belongs to Central Nervous System.
なぜ起こるのか
Duplicate acetylcholinesterase inhibition leading to additive cholinergic effects.
対処法
Avoid concurrent use and use one cholinesterase inhibitor at a time. When switching, stop one agent and start the other at the recommended initial dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DonepezilとRivastigmineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Donepezilのその他の相互作用
Rivastigmineのその他の相互作用
よくある質問
Can I take Donepezil with Rivastigmine?
MediHelp rates the interaction as major. Donepezil and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are cholinesterase inhibitors used for dementia, so combining them adds cholinergic toxicity without a proven benefit. Patients may develop nausea, vomiting, diarrhea, bradycardia and syncope.
How serious is the interaction between Donepezil and Rivastigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and use one cholinesterase inhibitor at a time. When switching, stop one agent and start the other at the recommended initial dose.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
