相互作用
Metoclopramide + Rivastigmine
重症度: 重大
Metoclopramide and Rivastigmine: major interaction.
最終更新日
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概要
Rivastigmine, a cholinesterase inhibitor, may increase the risk of extrapyramidal symptoms when given with metoclopramide. Cholinesterase inhibitors can also worsen parkinsonism, and metoclopramide's dopamine blockade adds to this. Neuroleptic malignant syndrome is a rare concern.
この相互作用をわかりやすく説明すると
Metoclopramide and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Rivastigmine belongs to Central Nervous System.
なぜ起こるのか
Metoclopramide blocks central D2 receptors while rivastigmine increases cholinergic tone, and the two together promote extrapyramidal effects; cholinergic effects on gut motility may also be additive.
対処法
Avoid the combination where possible, especially in patients with Parkinson disease or dementia. If needed, use the lowest metoclopramide dose briefly and monitor for tremor, rigidity and dystonia.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、MetoclopramideとRivastigmineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Metoclopramideのその他の相互作用
Rivastigmineのその他の相互作用
よくある質問
Can I take Metoclopramide with Rivastigmine?
MediHelp rates the interaction as major. Metoclopramide and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rivastigmine, a cholinesterase inhibitor, may increase the risk of extrapyramidal symptoms when given with metoclopramide. Cholinesterase inhibitors can also worsen parkinsonism, and metoclopramide's dopamine blockade adds to this. Neuroleptic malignant syndrome is a rare concern.
How serious is the interaction between Metoclopramide and Rivastigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in patients with Parkinson disease or dementia. If needed, use the lowest metoclopramide dose briefly and monitor for tremor, rigidity and dystonia.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
