相互作用
Oxybutynin + Rivastigmine
重症度: 重大
Oxybutynin and Rivastigmine: major interaction.
最終更新日
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概要
Rivastigmine, a cholinesterase inhibitor, and oxybutynin, a muscarinic antagonist, have opposing actions. Oxybutynin may reduce the cognitive benefit of rivastigmine and worsen confusion in dementia.
この相互作用をわかりやすく説明すると
Oxybutynin and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxybutynin belongs to Genitourinary; Rivastigmine belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism between cholinesterase inhibition and muscarinic receptor blockade.
対処法
Avoid oxybutynin in patients taking cholinesterase inhibitors; use a non-anticholinergic option such as mirabegron for bladder symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、OxybutyninとRivastigmineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Oxybutyninのその他の相互作用
Rivastigmineのその他の相互作用
よくある質問
Can I take Oxybutynin with Rivastigmine?
MediHelp rates the interaction as major. Oxybutynin and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rivastigmine, a cholinesterase inhibitor, and oxybutynin, a muscarinic antagonist, have opposing actions. Oxybutynin may reduce the cognitive benefit of rivastigmine and worsen confusion in dementia.
How serious is the interaction between Oxybutynin and Rivastigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oxybutynin in patients taking cholinesterase inhibitors; use a non-anticholinergic option such as mirabegron for bladder symptoms.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
