相互作用
Dulaglutide + Empagliflozin-linagliptin
重症度: 中等度
Dulaglutide and Empagliflozin-linagliptin: moderate interaction.
最終更新日
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概要
Combining dulaglutide with empagliflozin and linagliptin gives additive glucose lowering. Linagliptin and dulaglutide both act on the incretin pathway, so adding a DPP-4 inhibitor to a GLP-1 agonist offers little extra benefit and adds cost and pill burden.
この相互作用をわかりやすく説明すると
Dulaglutide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Empagliflozin-linagliptin belongs to Endocrine.
なぜ起こるのか
Overlapping incretin-pathway activity plus additive antihyperglycemic effect of SGLT2 inhibition.
対処法
Avoid routine combination of a DPP-4 inhibitor with a GLP-1 agonist. Monitor glucose, volume status and gastrointestinal tolerability.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DulaglutideとEmpagliflozin-linagliptinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Empagliflozin-linagliptinのその他の相互作用
Dulaglutideのその他の相互作用
よくある質問
Can I take Dulaglutide with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Dulaglutide and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining dulaglutide with empagliflozin and linagliptin gives additive glucose lowering. Linagliptin and dulaglutide both act on the incretin pathway, so adding a DPP-4 inhibitor to a GLP-1 agonist offers little extra benefit and adds cost and pill burden.
How serious is the interaction between Dulaglutide and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of a DPP-4 inhibitor with a GLP-1 agonist. Monitor glucose, volume status and gastrointestinal tolerability.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
