相互作用
Eluxadoline + Hydromorphone
重症度: 重大
Eluxadoline and Hydromorphone: major interaction.
最終更新日
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概要
Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
この相互作用をわかりやすく説明すると
Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Hydromorphone belongs to Musculoskeletal.
なぜ起こるのか
Additive inhibition of gastrointestinal motility via opioid receptor activity.
対処法
Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EluxadolineとHydromorphoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydromorphoneのその他の相互作用
Eluxadolineのその他の相互作用
よくある質問
Can I take Eluxadoline with Hydromorphone?
MediHelp rates the interaction as major. Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
How serious is the interaction between Eluxadoline and Hydromorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
