医薬品リファレンス
Eluxadoline
Eluxadoline is a medicine in the class gastrointestinal tract. It is used for irritable bowel syndrome.
- 薬効分類: Gastrointestinal Tract
- 効能・効果: irritable bowel syndrome
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Gastrointestinal Tract
- 一般的な剤形
- 錠剤
- 既知の相互作用
- 111 (重大: 10 · 中等度: 64 · 軽度: 37)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Mu-opioid receptor agonist, also a delta opioid receptor antagonist and a kappa opioid receptor agonist. In animals it interacts with opioid receptors in the gut.
成人の通常用量（添付文書の要約）
IBS-D: 100 mg orally twice daily with food
妊娠と授乳
- 妊娠
- Unknown No human studies; no birth defects in rats or rabbits at high exposures. EU label: avoid in pregnancy as a precaution.
- 授乳
- Unknown No human data; it passes into rat milk. EU label: decide whether to stop breastfeeding or treatment. LactMed: it has opioid activity, so an alternative is preferred, especially with a newborn or preterm infant.
報告されている副作用
- Constipation
- Nausea
- Abdominal pain
- Upper respiratory tract infection
- Vomiting
- Rash
禁忌
- Patients without a gallbladder
- Known or suspected biliary duct obstruction, or sphincter of Oddi disease or dysfunction
- Alcoholism, alcohol abuse or addiction, or more than 3 alcoholic beverages per day
注意が必要な方
- Pancreatitis, including fatal cases, mainly in patients without a gallbladder; most serious cases within a week of starting. Evaluate alcohol intake; stop immediately if symptoms occur.
- Sphincter of Oddi spasm; do not restart in patients who developed it or biliary duct obstruction.
- Serious hypersensitivity reactions including anaphylaxis, some after the first one or two doses.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (111)
- Alosetron + Eluxadoline Major
- Atropine + Eluxadoline Major
- Buprenorphine + Eluxadoline Major
- Cyclosporin + Eluxadoline Major
- Diphenoxylate-atropine + Eluxadoline Major
- Eluxadoline + Hydromorphone Major
- Eluxadoline + Loperamide Major
- Eluxadoline + Meperidine Major
- Eluxadoline + Morphine Major
- Eluxadoline + Oxymorphone Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Eluxadolineの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
WebでPro+を14日間無料でお試し。カード登録不要。
よくある質問
What is Eluxadoline used for?
Eluxadoline is a medicine in the class gastrointestinal tract. It is used for Irritable bowel syndrome.
What side effects have been reported with Eluxadoline?
Constipation, Nausea, Abdominal pain, Upper respiratory tract infection, Vomiting, Rash.
Can Eluxadoline be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human studies; no birth defects in rats or rabbits at high exposures. EU label: avoid in pregnancy as a precaution. Breastfeeding: Unknown. No human data; it passes into rat milk. EU label: decide whether to stop breastfeeding or treatment. LactMed: it has opioid activity, so an alternative is preferred, especially with a newborn or preterm infant.
What does Eluxadoline interact with?
MediHelp lists 111 known interactions for Eluxadoline. Major: 10 · Moderate: 64 · Minor: 37. The most serious include Alosetron, Atropine, Buprenorphine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
