相互作用
Cyclosporin + Eluxadoline
重症度: 重大
Cyclosporin and Eluxadoline: major interaction.
最終更新日
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概要
Cyclosporine inhibits OATP1B1 and can markedly increase eluxadoline exposure. This raises the risk of eluxadoline adverse effects such as constipation, pancreatitis, nausea and CNS effects.
この相互作用をわかりやすく説明すると
Cyclosporin and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.
なぜ起こるのか
Cyclosporine inhibits hepatic OATP1B1 uptake of eluxadoline, increasing systemic concentrations.
対処法
Reduce eluxadoline to 75 mg twice daily if coadministration is needed. Monitor for pancreatitis symptoms, constipation and sedation, or choose an alternative agent.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとEluxadolineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Eluxadolineのその他の相互作用
よくある質問
Can I take Cyclosporin with Eluxadoline?
MediHelp rates the interaction as major. Cyclosporin and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits OATP1B1 and can markedly increase eluxadoline exposure. This raises the risk of eluxadoline adverse effects such as constipation, pancreatitis, nausea and CNS effects.
How serious is the interaction between Cyclosporin and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily if coadministration is needed. Monitor for pancreatitis symptoms, constipation and sedation, or choose an alternative agent.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
