相互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Regorafenib
重症度: 重大
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Regorafenib: major interaction.
最終更新日
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概要
Cobicistat is a strong CYP3A4 inhibitor and may increase regorafenib concentrations while reducing its active metabolites, making outcomes unpredictable and raising toxicity risk.
この相互作用をわかりやすく説明すると
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Cobicistat inhibits CYP3A4 metabolism of regorafenib.
対処法
Avoid if possible and use an unboosted antiretroviral regimen. Otherwise monitor liver function and tolerability.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Elvitegravir / cobicistat / emtricitabine / tenofovir dfとRegorafenibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Regorafenibのその他の相互作用
よくある質問
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Regorafenib?
MediHelp rates the interaction as major. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 inhibitor and may increase regorafenib concentrations while reducing its active metabolites, making outcomes unpredictable and raising toxicity risk.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an unboosted antiretroviral regimen. Otherwise monitor liver function and tolerability.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
