相互作用
Clarithromycin + Regorafenib
重症度: 重大
Clarithromycin and Regorafenib: major interaction.
最終更新日
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概要
Clarithromycin is a strong CYP3A4 inhibitor, and regorafenib is cleared largely by CYP3A4. Raised regorafenib exposure can lead to regorafenib toxicity including hepatotoxicity, hand-foot reaction and hypertension.
この相互作用をわかりやすく説明すると
Clarithromycin and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Regorafenib belongs to Oncology.
なぜ起こるのか
CYP3A4 inhibition by clarithromycin reduces first-pass and systemic clearance of regorafenib
対処法
Avoid if an alternative exists; otherwise reduce the regorafenib dose per labelling, monitor closely for toxicity and recheck after the inhibitor is stopped.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClarithromycinとRegorafenibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Regorafenibのその他の相互作用
よくある質問
Can I take Clarithromycin with Regorafenib?
MediHelp rates the interaction as major. Clarithromycin and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin is a strong CYP3A4 inhibitor, and regorafenib is cleared largely by CYP3A4. Raised regorafenib exposure can lead to regorafenib toxicity including hepatotoxicity, hand-foot reaction and hypertension.
How serious is the interaction between Clarithromycin and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative exists; otherwise reduce the regorafenib dose per labelling, monitor closely for toxicity and recheck after the inhibitor is stopped.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
