相互作用
Dabrafenib + Regorafenib
重症度: 重大
Dabrafenib and Regorafenib: major interaction.
最終更新日
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概要
Dabrafenib induces CYP3A4 and can lower regorafenib exposure, possibly reducing anticancer efficacy while increasing the active metabolite M-5.
この相互作用をわかりやすく説明すると
Dabrafenib and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Regorafenib belongs to Oncology.
なぜ起こるのか
Dabrafenib induces CYP3A4, accelerating regorafenib clearance.
対処法
Avoid concomitant use of strong CYP3A4 inducers with regorafenib. If needed, monitor for loss of efficacy and toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DabrafenibとRegorafenibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Regorafenibのその他の相互作用
Dabrafenibのその他の相互作用
よくある質問
Can I take Dabrafenib with Regorafenib?
MediHelp rates the interaction as major. Dabrafenib and Regorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and can lower regorafenib exposure, possibly reducing anticancer efficacy while increasing the active metabolite M-5.
How serious is the interaction between Dabrafenib and Regorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of strong CYP3A4 inducers with regorafenib. If needed, monitor for loss of efficacy and toxicity.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
