相互作用
Enasidenib + Rosuvastatin
重症度: 重大
Enasidenib and Rosuvastatin: major interaction.
最終更新日
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概要
Enasidenib can raise rosuvastatin exposure, increasing the risk of statin-related myopathy and rhabdomyolysis.
この相互作用をわかりやすく説明すると
Enasidenib and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enasidenib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
なぜ起こるのか
Enasidenib inhibits the transporters OATP1B1, OATP1B3 and BCRP, which are involved in rosuvastatin uptake and efflux.
対処法
Avoid if possible; if unavoidable, use the lowest effective rosuvastatin dose per its labeling and monitor for muscle pain, weakness and CK elevation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EnasidenibとRosuvastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Enasidenibのその他の相互作用
Rosuvastatinのその他の相互作用
よくある質問
Can I take Enasidenib with Rosuvastatin?
MediHelp rates the interaction as major. Enasidenib and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enasidenib can raise rosuvastatin exposure, increasing the risk of statin-related myopathy and rhabdomyolysis.
How serious is the interaction between Enasidenib and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if unavoidable, use the lowest effective rosuvastatin dose per its labeling and monitor for muscle pain, weakness and CK elevation.
What other medicines interact with Enasidenib?
MediHelp also lists interactions of Enasidenib with, for example, Desogestrel-ethinyl estradiol, Ethinyl estradiol-levonorgestrel, Ethinyl estradiol-norgestimate. The full list is on the Enasidenib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
