相互作用
Enasidenib + Ethinyl estradiol-levonorgestrel
重症度: 中等度
Enasidenib and Ethinyl estradiol-levonorgestrel: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
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概要
Enasidenib may alter exposure to hormonal contraceptives, and the direction and size of the change are not well defined. A reduction could compromise contraceptive efficacy, which matters because enasidenib is teratogenic.
この相互作用をわかりやすく説明すると
Enasidenib and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enasidenib belongs to Oncology; Ethinyl estradiol-levonorgestrel belongs to Endocrine.
なぜ起こるのか
The mechanism is not established; enasidenib may modulate CYP enzymes or transporters involved in contraceptive disposition.
対処法
Advise an additional non-hormonal barrier method during enasidenib therapy. Do not rely solely on hormonal contraception.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EnasidenibとEthinyl estradiol-levonorgestrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ethinyl estradiol-levonorgestrelのその他の相互作用
- Ethinyl estradiol-levonorgestrel + Fezolinetant 併用禁忌
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir 併用禁忌
- Ethinyl estradiol-levonorgestrel + Tranexamic acid 併用禁忌
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel 重大
- Amobarbital + Ethinyl estradiol-levonorgestrel 重大
- Anastrozole + Ethinyl estradiol-levonorgestrel 重大
Enasidenibのその他の相互作用
よくある質問
Can I take Enasidenib with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as moderate. Enasidenib and Ethinyl estradiol-levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enasidenib may alter exposure to hormonal contraceptives, and the direction and size of the change are not well defined. A reduction could compromise contraceptive efficacy, which matters because enasidenib is teratogenic.
How serious is the interaction between Enasidenib and Ethinyl estradiol-levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal barrier method during enasidenib therapy. Do not rely solely on hormonal contraception.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
