相互作用
Enasidenib + Levonorgestrel
重症度: 中等度
Enasidenib and Levonorgestrel: moderate interaction.
最終更新日
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概要
Enasidenib may induce CYP3A4 and alter hormonal contraceptive concentrations, and the labeling advises that its effect on contraceptives is uncertain. Reduced efficacy is possible. Enasidenib also carries embryo-fetal risk, making reliable contraception important.
この相互作用をわかりやすく説明すると
Enasidenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enasidenib belongs to Oncology; Levonorgestrel belongs to Endocrine.
なぜ起こるのか
Possible induction of CYP3A4 by enasidenib altering levonorgestrel clearance; not fully established.
対処法
Use an additional reliable non-hormonal contraceptive method during enasidenib therapy. Do not rely on hormonal contraception alone.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EnasidenibとLevonorgestrelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Levonorgestrelのその他の相互作用
Enasidenibのその他の相互作用
よくある質問
Can I take Enasidenib with Levonorgestrel?
MediHelp rates the interaction as moderate. Enasidenib and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enasidenib may induce CYP3A4 and alter hormonal contraceptive concentrations, and the labeling advises that its effect on contraceptives is uncertain. Reduced efficacy is possible. Enasidenib also carries embryo-fetal risk, making reliable contraception important.
How serious is the interaction between Enasidenib and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an additional reliable non-hormonal contraceptive method during enasidenib therapy. Do not rely on hormonal contraception alone.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
