相互作用
Etodolac + Pemetrexed
重症度: 重大
Etodolac and Pemetrexed: major interaction.
最終更新日
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概要
NSAIDs can raise pemetrexed exposure in patients with reduced kidney function, increasing the risk of myelosuppression, mucositis and renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.
この相互作用をわかりやすく説明すると
Etodolac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
なぜ起こるのか
NSAID-related reduction in renal function and competition for tubular secretion decrease pemetrexed clearance.
対処法
Avoid etodolac around pemetrexed dosing where possible and use an alternative analgesic. If it is needed, monitor blood counts and renal function and follow labeled NSAID interruption windows based on half-life.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、EtodolacとPemetrexedの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Etodolacのその他の相互作用
Pemetrexedのその他の相互作用
よくある質問
Can I take Etodolac with Pemetrexed?
MediHelp rates the interaction as major. Etodolac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can raise pemetrexed exposure in patients with reduced kidney function, increasing the risk of myelosuppression, mucositis and renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.
How serious is the interaction between Etodolac and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid etodolac around pemetrexed dosing where possible and use an alternative analgesic. If it is needed, monitor blood counts and renal function and follow labeled NSAID interruption windows based on half-life.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
