相互作用
Fluconazole + Glibenclamide
重症度: 重大
Fluconazole and Glibenclamide: major interaction.
最終更新日 出典: US FDA label
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概要
Fluconazole raises glyburide levels and prolongs its half-life, increasing the risk of significant hypoglycemia. Severe episodes have been reported with sulfonylureas and azole antifungals.
この相互作用をわかりやすく説明すると
Fluconazole and Glibenclamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Glibenclamide belongs to Endocrine.
なぜ起こるのか
Fluconazole inhibits CYP2C9 (and CYP3A4), decreasing glyburide metabolism.
対処法
Monitor blood glucose closely and lower the glyburide dose when starting fluconazole. Consider an alternative antidiabetic or antifungal if hypoglycemia occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FluconazoleとGlibenclamideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Fluconazoleのその他の相互作用
Glibenclamideのその他の相互作用
よくある質問
Can I take Fluconazole with Glibenclamide?
MediHelp rates the interaction as major. Fluconazole and Glibenclamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole raises glyburide levels and prolongs its half-life, increasing the risk of significant hypoglycemia. Severe episodes have been reported with sulfonylureas and azole antifungals.
How serious is the interaction between Fluconazole and Glibenclamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and lower the glyburide dose when starting fluconazole. Consider an alternative antidiabetic or antifungal if hypoglycemia occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
