相互作用
Domperidone + Fluconazole
重症度: 併用禁忌
Domperidone and Fluconazole: contraindicated interaction.
最終更新日 出典: EMA SmPC, US FDA label
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概要
Co-administration is contraindicated. Fluconazole raises domperidone plasma levels, and both drugs prolong the QT interval. Together they increase the risk of QT prolongation, torsades de pointes, serious ventricular arrhythmias, and sudden cardiac death.
この相互作用をわかりやすく説明すると
Domperidone and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Domperidone belongs to Gastrointestinal Tract; Fluconazole belongs to Anti Fungals.
なぜ起こるのか
Pharmacokinetic: Fluconazole is a moderate-to-strong CYP3A4 inhibitor (dose-dependent). Domperidone is extensively metabolized by CYP3A4, so fluconazole reduces its clearance and increases exposure. Pharmacodynamic: Domperidone blocks hERG channels and prolongs QTc, and fluconazole independently prolongs QTc. The effects on cardiac repolarization are additive.
対処法
Avoid the combination. If antifungal therapy is required, stop domperidone.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、DomperidoneとFluconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Fluconazoleのその他の相互作用
Domperidoneのその他の相互作用
よくある質問
Can I take Domperidone with Fluconazole?
MediHelp rates the interaction as contraindicated. Domperidone and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Co-administration is contraindicated. Fluconazole raises domperidone plasma levels, and both drugs prolong the QT interval. Together they increase the risk of QT prolongation, torsades de pointes, serious ventricular arrhythmias, and sudden cardiac death.
How serious is the interaction between Domperidone and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If antifungal therapy is required, stop domperidone.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
