相互作用
Fluconazole + Levoketoconazole
重症度: 併用禁忌
Fluconazole and Levoketoconazole: contraindicated interaction.
最終更新日
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概要
Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
この相互作用をわかりやすく説明すると
Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Levoketoconazole belongs to Endocrine.
なぜ起こるのか
Additive QT prolongation, with possible metabolic inhibition raising levoketoconazole levels.
対処法
Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FluconazoleとLevoketoconazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fluconazoleのその他の相互作用
Levoketoconazoleのその他の相互作用
よくある質問
Can I take Fluconazole with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
How serious is the interaction between Fluconazole and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
