Drug interactions
Fluconazole + Levoketoconazole
Severity: Contraindicated
Fluconazole and Levoketoconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
What this interaction means in plain words
Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluconazole belongs to Anti Fungals; Levoketoconazole belongs to Endocrine.
Why it happens
Additive QT prolongation, with possible metabolic inhibition raising levoketoconazole levels.
What to do
Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Fluconazole and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both azoles prolong the QT interval, and combined use increases the risk of torsades de pointes. Fluconazole also inhibits CYP3A4, which may increase levoketoconazole exposure.
How serious is the interaction between Fluconazole and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use only one azole at a time. Monitor ECG and liver function if levoketoconazole is continued.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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