相互作用
Amisulpride + Memantine-donepezil
重症度: 重大
Amisulpride and Memantine-donepezil: major interaction.
最終更新日
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概要
Donepezil and amisulpride both prolong the QT interval, raising the risk of torsades de pointes. Risk is greater with bradycardia, electrolyte disturbance or renal impairment.
この相互作用をわかりやすく説明すると
Amisulpride and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation.
対処法
Avoid if possible; otherwise perform ECG monitoring and correct electrolytes. Consider a lower-risk alternative antipsychotic.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとMemantine-donepezilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Memantine-donepezilのその他の相互作用
Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Memantine-donepezil?
MediHelp rates the interaction as major. Amisulpride and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Donepezil and amisulpride both prolong the QT interval, raising the risk of torsades de pointes. Risk is greater with bradycardia, electrolyte disturbance or renal impairment.
How serious is the interaction between Amisulpride and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise perform ECG monitoring and correct electrolytes. Consider a lower-risk alternative antipsychotic.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
