相互作用
Glimepiride-pioglitazone + Insulin aspart
重症度: 重大
Glimepiride-pioglitazone and Insulin aspart: major interaction.
最終更新日
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概要
Combining insulin with glimepiride and pioglitazone increases the risk of hypoglycemia. Insulin with pioglitazone also raises the risk of fluid retention, edema and heart failure.
この相互作用をわかりやすく説明すると
Glimepiride-pioglitazone and Insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glimepiride-pioglitazone belongs to Endocrine; Insulin aspart belongs to Endocrine.
なぜ起こるのか
Additive glucose lowering, and thiazolidinedione-induced sodium and fluid retention is amplified by insulin.
対処法
Reduce insulin or sulfonylurea doses as needed and monitor glucose. Watch for weight gain, edema and heart failure symptoms, particularly in patients with cardiac risk.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Glimepiride-pioglitazoneとInsulin aspartの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glimepiride-pioglitazoneのその他の相互作用
Insulin aspartのその他の相互作用
よくある質問
Can I take Glimepiride-pioglitazone with Insulin aspart?
MediHelp rates the interaction as major. Glimepiride-pioglitazone and Insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining insulin with glimepiride and pioglitazone increases the risk of hypoglycemia. Insulin with pioglitazone also raises the risk of fluid retention, edema and heart failure.
How serious is the interaction between Glimepiride-pioglitazone and Insulin aspart?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce insulin or sulfonylurea doses as needed and monitor glucose. Watch for weight gain, edema and heart failure symptoms, particularly in patients with cardiac risk.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin degludec. The full list is on the Glimepiride-pioglitazone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
