相互作用
Glimepiride-pioglitazone + Sulfamethoxazole
重症度: 重大
Glimepiride-pioglitazone and Sulfamethoxazole: major interaction.
最終更新日
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概要
Sulfamethoxazole, usually given with trimethoprim, can enhance the hypoglycemic effect of glimepiride. Severe hypoglycemia has been reported with sulfonylurea and co-trimoxazole combinations, especially in older patients or those with renal impairment.
この相互作用をわかりやすく説明すると
Glimepiride-pioglitazone and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Sulfamethoxazole inhibits CYP2C9 metabolism of sulfonylureas and may displace them from protein binding, increasing glimepiride exposure.
対処法
Monitor blood glucose frequently during co-trimoxazole therapy and reduce the glimepiride dose if needed. Consider an alternative antibiotic in high-risk patients.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Glimepiride-pioglitazoneとSulfamethoxazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glimepiride-pioglitazoneのその他の相互作用
よくある質問
Can I take Glimepiride-pioglitazone with Sulfamethoxazole?
MediHelp rates the interaction as major. Glimepiride-pioglitazone and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given with trimethoprim, can enhance the hypoglycemic effect of glimepiride. Severe hypoglycemia has been reported with sulfonylurea and co-trimoxazole combinations, especially in older patients or those with renal impairment.
How serious is the interaction between Glimepiride-pioglitazone and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during co-trimoxazole therapy and reduce the glimepiride dose if needed. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
