相互作用
Golimumab + Vedolizumab
重症度: 重大
Golimumab and Vedolizumab: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.
この相互作用をわかりやすく説明すると
Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Golimumab belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
なぜ起こるのか
Additive immunosuppression via gut-selective integrin blockade and TNF-alpha inhibition.
対処法
Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GolimumabとVedolizumabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Golimumabのその他の相互作用
Vedolizumabのその他の相互作用
よくある質問
Can I take Golimumab with Vedolizumab?
MediHelp rates the interaction as major. Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.
How serious is the interaction between Golimumab and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
