Drug interactions
Golimumab + Vedolizumab
Severity: Major
Golimumab and Vedolizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.
What this interaction means in plain words
Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Golimumab belongs to Musculoskeletal; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression via gut-selective integrin blockade and TNF-alpha inhibition.
What to do
Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Golimumab and Vedolizumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
- Upadacitinib + Vedolizumab Major
Frequently asked questions
Can I take Golimumab with Vedolizumab?
MediHelp rates the interaction as major. Golimumab and Vedolizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vedolizumab blocks gut-selective integrin-mediated lymphocyte trafficking and golimumab blocks systemic TNF-alpha. Labeling for vedolizumab advises against use with TNF blockers because of a possible increase in infection risk.
How serious is the interaction between Golimumab and Vedolizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination use. Transition from one agent to the other with a planned switch and monitor for infection.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
