相互作用
Griseofulvin + Lapatinib
重症度: 重大
Griseofulvin and Lapatinib: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Griseofulvin may considerably lower lapatinib exposure, which could compromise anticancer efficacy. Lapatinib is a CYP3A4 substrate whose levels fall markedly with inducers.
この相互作用をわかりやすく説明すると
Griseofulvin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Griseofulvin belongs to Anti Fungals; Lapatinib belongs to Oncology.
なぜ起こるのか
Griseofulvin-mediated CYP3A4 induction increases lapatinib clearance.
対処法
Prefer a non-inducing antifungal. If unavoidable, lapatinib dose escalation as per labeling for strong inducers should be considered with close monitoring of response and toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、GriseofulvinとLapatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Griseofulvinのその他の相互作用
Lapatinibのその他の相互作用
よくある質問
Can I take Griseofulvin with Lapatinib?
MediHelp rates the interaction as major. Griseofulvin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may considerably lower lapatinib exposure, which could compromise anticancer efficacy. Lapatinib is a CYP3A4 substrate whose levels fall markedly with inducers.
How serious is the interaction between Griseofulvin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antifungal. If unavoidable, lapatinib dose escalation as per labeling for strong inducers should be considered with close monitoring of response and toxicity.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
