相互作用
Cyclosporin + Griseofulvin
重症度: 重大
Cyclosporin and Griseofulvin: major interaction.
最終更新日
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概要
Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
この相互作用をわかりやすく説明すると
Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Griseofulvin belongs to Anti Fungals.
なぜ起こるのか
Griseofulvin induces hepatic and intestinal CYP3A4, accelerating cyclosporine metabolism.
対処法
Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとGriseofulvinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Griseofulvinのその他の相互作用
よくある質問
Can I take Cyclosporin with Griseofulvin?
MediHelp rates the interaction as major. Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
How serious is the interaction between Cyclosporin and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
