相互作用
Ethinyl estradiol-drospirenone + Griseofulvin
重症度: 重大
Ethinyl estradiol-drospirenone and Griseofulvin: major interaction.
最終更新日 出典: US FDA label
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概要
Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
この相互作用をわかりやすく説明すると
Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-drospirenone belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
なぜ起こるのか
Griseofulvin is thought to induce hepatic enzymes (CYP3A4) and increase metabolism of ethinyl estradiol and the progestin, lowering their exposure.
対処法
Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ethinyl estradiol-drospirenoneとGriseofulvinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Ethinyl estradiol-drospirenoneのその他の相互作用
- Ethinyl estradiol-drospirenone + Fezolinetant 併用禁忌
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir 併用禁忌
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir 併用禁忌
- Ethinyl estradiol-drospirenone + Tranexamic acid 併用禁忌
- Aminocaproic acid + Ethinyl estradiol-drospirenone 重大
- Amobarbital + Ethinyl estradiol-drospirenone 重大
Griseofulvinのその他の相互作用
よくある質問
Can I take Ethinyl estradiol-drospirenone with Griseofulvin?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
How serious is the interaction between Ethinyl estradiol-drospirenone and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
