相互作用
Hydrocodone + Olanzapine / samidorphan
重症度: 併用禁忌
Hydrocodone and Olanzapine / samidorphan: contraindicated interaction.
最終更新日
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概要
Samidorphan blocks opioid receptors, reducing hydrocodone analgesia and potentially precipitating withdrawal in opioid-dependent patients. Escalating opioid doses to overcome the blockade is dangerous.
この相互作用をわかりやすく説明すると
Hydrocodone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Samidorphan is a mu-opioid receptor antagonist that opposes hydrocodone's agonist effects.
対処法
Ensure at least 7 days opioid-free for short-acting opioids before starting. Use an alternative antipsychotic in patients requiring opioids.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、HydrocodoneとOlanzapine / samidorphanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydrocodoneのその他の相互作用
よくある質問
Can I take Hydrocodone with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Hydrocodone and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing hydrocodone analgesia and potentially precipitating withdrawal in opioid-dependent patients. Escalating opioid doses to overcome the blockade is dangerous.
How serious is the interaction between Hydrocodone and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure at least 7 days opioid-free for short-acting opioids before starting. Use an alternative antipsychotic in patients requiring opioids.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
