相互作用
Hydrocodone + Phenelzine
重症度: 併用禁忌
Hydrocodone and Phenelzine: contraindicated interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.
この相互作用をわかりやすく説明すると
Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydrocodone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
なぜ起こるのか
Inhibition of monoamine oxidase raises serotonergic and noradrenergic activity, with possible potentiation of opioid CNS effects.
対処法
Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、HydrocodoneとPhenelzineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydrocodoneのその他の相互作用
Phenelzineのその他の相互作用
よくある質問
Can I take Hydrocodone with Phenelzine?
MediHelp rates the interaction as contraindicated. Hydrocodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAOIs combined with opioids can cause serotonin syndrome or severe opioid toxicity including respiratory depression and coma. Labeling advises against opioid use during and for 14 days after MAOI therapy.
How serious is the interaction between Hydrocodone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydrocodone during MAOI therapy and for 14 days after stopping. Choose a non-serotonergic analgesic strategy and monitor closely if an opioid is unavoidable.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
