相互作用
Ifosfamide + Sargramostim
重症度: 中等度
Ifosfamide and Sargramostim: moderate interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Sargramostim stimulates proliferation of myeloid progenitor cells, which makes them more susceptible to damage from cytotoxic drugs. Giving it close to ifosfamide may worsen myelosuppression or blunt its intended benefit.
この相互作用をわかりやすく説明すると
Ifosfamide and Sargramostim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Sargramostim belongs to Miscellaneous.
なぜ起こるのか
Growth factor-driven cycling of hematopoietic progenitors increases their sensitivity to cytotoxic chemotherapy.
対処法
Do not give sargramostim within 24 hours before or after ifosfamide. Monitor blood counts throughout treatment.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IfosfamideとSargramostimの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Ifosfamideのその他の相互作用
Sargramostimのその他の相互作用
よくある質問
Can I take Ifosfamide with Sargramostim?
MediHelp rates the interaction as moderate. Ifosfamide and Sargramostim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sargramostim stimulates proliferation of myeloid progenitor cells, which makes them more susceptible to damage from cytotoxic drugs. Giving it close to ifosfamide may worsen myelosuppression or blunt its intended benefit.
How serious is the interaction between Ifosfamide and Sargramostim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give sargramostim within 24 hours before or after ifosfamide. Monitor blood counts throughout treatment.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
