医薬品リファレンス
Sargramostim
Sargramostim is a medicine in the class miscellaneous. It is used for acute lymphocytic leukemia.
- 薬効分類: Miscellaneous
- 効能・効果: acute lymphocytic leukemia
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- L03AA09
- 一般的な剤形
- 注射剤
- 一般的な規格
- 250 mcg/ml
- 既知の相互作用
- 3 (中等度: 1 · 軽度: 2)
- 商品名
- 2
- 国・市場
- 2
何に使われるか
作用のしくみ
Sargramostim (GM-CSF) is a colony-stimulating factor that supports survival, clonal expansion and differentiation of hematopoietic progenitor cells, driving granulocyte-macrophage lineages (neutrophils, monocytes/macrophages, dendritic cells) and activating mature granulocytes and macrophages.
成人の通常用量（添付文書の要約）
AML, neutrophil recovery after induction chemotherapy: 250 mcg/m2/day IV over 4 hours, starting about day 11 or 4 days after chemotherapy if day 10 marrow hypoplastic with <5% blasts; continue until ANC >1500 cells/mm3 for 3 consecutive days or maximum 42 days
妊娠と授乳
- 妊娠
- Unknown Limited human data. In rabbits it increased miscarriage at about 1.3 times human exposure. If needed in pregnancy, reconstitute only with sterile water (no benzyl alcohol). Filgrastim has more pregnancy data.
- 授乳
- Safe No data with injected use; GM-CSF is a normal milk component and is largely digested in the infant's gut. US label: do not breastfeed during treatment and for at least 2 weeks after (lower pup survival in rabbits). LactMed: unlikely to affect the infant.
報告されている副作用
- Fever
- Nausea
- Diarrhea
- Vomiting
- Mucous membrane disorder
- Alopecia
禁忌
- History of serious allergic reactions, including anaphylaxis, to human GM-CSF such as sargramostim, yeast-derived products, or any component of the product
注意が必要な方
- Serious hypersensitivity reactions including anaphylaxis: discontinue permanently for serious allergic reactions
- Infusion-related reactions (respiratory distress, hypoxia, flushing, hypotension, syncope, tachycardia), especially with pre-existing lung disease
- Do not give within 24 hours before or after chemotherapy or radiotherapy because of severe myelosuppression risk
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (3)
- Ifosfamide + Sargramostim Moderate
- Hydrocortisone + Sargramostim Minor
- Lithium + Sargramostim Minor
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Sargramostimの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
WebでPro+を7日間無料でお試し。カード登録不要。
同じ分類のほかの薬剤
よくある質問
What is Sargramostim used for?
Sargramostim is a medicine in the class miscellaneous. It is used for Acute lymphocytic leukemia, Hodgkin lymphoma, Non-hodgkin lymphoma, Radiation syndrome.
What side effects have been reported with Sargramostim?
Fever, Nausea, Diarrhea, Vomiting, Mucous membrane disorder, Alopecia.
Can Sargramostim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. In rabbits it increased miscarriage at about 1.3 times human exposure. If needed in pregnancy, reconstitute only with sterile water (no benzyl alcohol). Filgrastim has more pregnancy data. Breastfeeding: Safe. No data with injected use; GM-CSF is a normal milk component and is largely digested in the infant's gut. US label: do not breastfeed during treatment and for at least 2 weeks after (lower pup survival in rabbits). LactMed: unlikely to affect the infant.
What does Sargramostim interact with?
MediHelp lists 3 known interactions for Sargramostim. Moderate: 1 · Minor: 2. The most serious include Ifosfamide, Hydrocortisone, Lithium.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
