相互作用
Indomethacin + Ketorolac intranasal
重症度: 併用禁忌
Indomethacin and Ketorolac intranasal: contraindicated interaction.
最終更新日
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概要
Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
この相互作用をわかりやすく説明すると
Indomethacin and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive cyclooxygenase inhibition causing GI mucosal injury, platelet inhibition and reduced renal prostaglandins.
対処法
Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、IndomethacinとKetorolac intranasalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Indomethacinのその他の相互作用
よくある質問
Can I take Indomethacin with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Indomethacin and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac is contraindicated with other NSAIDs because the combination increases the risk of gastrointestinal bleeding, perforation and renal impairment. Intranasal ketorolac is systemically absorbed, so the warning applies.
How serious is the interaction between Indomethacin and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Use one NSAID at a time and choose a non-NSAID analgesic such as paracetamol if more analgesia is needed.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Indomethacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
