相互作用
Amiloride + Indomethacin
重症度: 重大
Amiloride and Indomethacin: major interaction.
最終更新日
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概要
Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.
この相互作用をわかりやすく説明すると
Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
なぜ起こるのか
Additive potassium retention: amiloride blocks ENaC and indomethacin suppresses prostaglandin-mediated renin and aldosterone and renal potassium excretion.
対処法
Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmilorideとIndomethacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Indomethacinのその他の相互作用
Amilorideのその他の相互作用
よくある質問
Can I take Amiloride with Indomethacin?
MediHelp rates the interaction as major. Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.
How serious is the interaction between Amiloride and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
